Combined strategy of α 9-integrin transduction and AEIDGIEL peptide-functionalized fibrin gel biomaterials to promote mature DRG neurite growth
the proposed combination therapy of α9-integrin and fibrin gel biomaterials incorporating AEIDGIEL peptide shows promise for addressing the complex challenges of spinal cord injury and promoting effective neural regeneration, laying the foundation for further <i>in vivo</i> research.
Authors
- Lars Roll
- Andréas Faissner (ORCID: https://orcid.org/0000-0002-2211-8259)
- Jessica C. F. Kwok (ORCID: https://orcid.org/0000-0002-9798-9083)
- Fred de Winter (ORCID: https://orcid.org/0000-0002-3042-2429)
- James W. Fawcett (ORCID: https://orcid.org/0000-0002-7990-4568)
- Jacqueline Reinhard (ORCID: https://orcid.org/0000-0002-4227-0493)
- Pavla Jendelová (ORCID: https://orcid.org/0000-0002-4644-9212)
- Anda Cimpean (ORCID: https://orcid.org/0009-0002-3550-2441)
Institutions
- Netherlands Institute for Neuroscience (NL)
- University of Leeds (GB)
- Charles University (CZ)
- University of Cambridge (GB)
- Czech Academy of Sciences, Institute of Experimental Medicine (CZ)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Frontiers in Cellular Neuroscience
- Published
- 2025-04-01
- DOI
- https://doi.org/10.3389/fncel.2025.1568004
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerstvo Školství, Mládeže a Tělovýchovy
- Grantová Agentura České Republiky
- Medical Research Council