Two chemotherapeutic agents expand stem-like CD62L+CD8+ T cells in antitumor immune responses
The present study demonstrated that both DAC and 5-FU promoted the differentiation of stem-like CD8<sup>+</sup> T<sub>TSM</sub> cells in TdLNs and significantly enhanced the differentiation and expansion of stem-like CD62L<sup>+</sup> CD8<sup>+</sup> Tpex and CX3CR1<sup>+</sup> Tex<sup>int</sup> cells in tumor microenvironment. The knockout of Eomes partially influenced the role of DAC in promoting the differentiation and expansion of stem-like CD8<sup>+</sup> T cells.
Authors
- Yujian Xia
- Haolin Jiang
- Jianling Gao
- Yan Pan (ORCID: https://orcid.org/0000-0003-4307-3616)
- Xiaokang Ruan
- Xin Zhao (ORCID: https://orcid.org/0000-0002-9303-7675)
- Shengjia Wang (ORCID: https://orcid.org/0000-0003-2347-2898)
- Chengfu Yuan
- Linwei Wu (ORCID: https://orcid.org/0000-0002-2242-7887)
- Zhaoqiang Chen (ORCID: https://orcid.org/0000-0003-3380-3689)
- Yao Li (ORCID: https://orcid.org/0000-0002-7872-1495)
- Zhang Li (ORCID: https://orcid.org/0000-0001-9242-0763)
- Jin Wang (ORCID: https://orcid.org/0000-0002-1695-4875)
- Zijian Tang (ORCID: https://orcid.org/0000-0002-7981-4239)
Institutions
- Soochow University (CN)
- Wuhan Dongxihu District People Hospital (CN)
- Second Affiliated Hospital of Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
- The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.3389/fimmu.2025.1533857
- Citations
- 3
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 3.14