Curcumin Analog J7 Attenuates Liver Fibrosis and Metabolic Dysregulation in a Rat Model of Type 2 Diabetes via Modulation of TGF-β/Smad and NF-κB/BCL-2/BAX Pathways
J7 demonstrates potential as a therapeutic agent for managing liver complications in type 2 diabetes, effectively attenuating liver fibrosis and regulating metabolism through the modulation of key signaling pathways and proteins.
Authors
- Zhichao Zhao (ORCID: https://orcid.org/0000-0002-0994-6922)
- Qingling Yang
- Jun Ma (ORCID: https://orcid.org/0000-0002-6343-8187)
- Deep K Vaishnani (ORCID: https://orcid.org/0000-0001-7666-0986)
- Sheng Xue (ORCID: https://orcid.org/0000-0003-4578-9677)
- Furong Ying
- Wei C. (ORCID: https://orcid.org/0000-0002-2202-8608)
- Tong Yang (ORCID: https://orcid.org/0000-0003-4577-4184)
- NokI Lei
- Congying Wang (ORCID: https://orcid.org/0000-0002-2923-0809)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Yuxian People's Hospital (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/dddt.s511372
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42