Intrastriatal injection of alpha-synuclein preformed fibrils to rats results in L-DOPA reversible sensorimotor impairments and alterations in non-motor function
Thus, using the present <i>α</i>-syn PFF surgical parameters, sufficient nigrostriatal degeneration can be achieved to manifest significant motor and non-motor deficits. These rat <i>α</i>-syn PFF surgical parameters will be important for preclinical assessment of novel diseasemodifying therapies.
Authors
- Michael Kubik
- Jack W. Lipton (ORCID: https://orcid.org/0000-0003-0991-8275)
- Joseph R. Patterson (ORCID: https://orcid.org/0000-0003-0926-7396)
- Kelvin C. Luk (ORCID: https://orcid.org/0000-0002-6591-6269)
- Katrina Linning‐Duffy
- Anna C. Stoll (ORCID: https://orcid.org/0000-0001-7135-121X)
- Danielle Herman
- Kathryn Miller (ORCID: https://orcid.org/0000-0002-7464-1981)
- Kathy Steece‐Collier (ORCID: https://orcid.org/0000-0002-8137-2310)
- Sheila M. Fleming (ORCID: https://orcid.org/0000-0001-7090-8274)
- Allyson Cole-Strauss
- Lili Yan (ORCID: https://orcid.org/0000-0002-6261-2542)
- Edward J. Hamad
- Caryl E. Sortwell (ORCID: https://orcid.org/0000-0003-2571-6753)
- John G. Holden (ORCID: https://orcid.org/0000-0001-8644-9500)
- Megan F. Duffy (ORCID: https://orcid.org/0000-0003-0094-0900)
- S. Mark Scott (ORCID: https://orcid.org/0000-0002-7997-1533)
- Christopher J. Kemp
- Nathan C. Kuhn
Institutions
- University of Cincinnati (US)
- University of Pennsylvania (US)
- Michigan State University (US)
- Northeast Ohio Medical University (US)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-04-01
- DOI
- https://doi.org/10.3389/fnins.2025.1556447
- Citations
- 2
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- National Institute of Neurological Disorders and Stroke
- National Institute of Environmental Health Sciences