Synthesis and Analgesic and Anti-inflammatory Activity of 4-(2-Aryl-3-aroyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic Acids
4-(2-Aryl-3-aroyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acids were synthesized by three-component condensation of methyl aroylpyruvates, aromatic aldehydes, and 4-aminobenzoic acid (PABA) in glacial acetic acid. Their structure was confirmed by 1H and 13C NMR and IR spectra, as well as by X-ray analysis, and their analgesic and anti-inflammatory activity was studied.
Authors
- A. V. Romanova (ORCID: https://orcid.org/0000-0002-2516-2458)
- В. Л. Гейн (ORCID: https://orcid.org/0000-0002-8512-0399)
- С. В. Чащина (ORCID: https://orcid.org/0000-0003-4427-310X)
- М. В. Дмитриев (ORCID: https://orcid.org/0000-0002-8817-0543)
- O. V. Bobrovskaya (ORCID: https://orcid.org/0000-0002-3394-9031)
- D. V. Chalkov (ORCID: https://orcid.org/0009-0001-0367-3863)
Institutions
- Solikamsk State Pedagogical Institute (RU)
- Perm State Pharmaceutical Academy (RU)
Publication Details
- Journal
- Russian Journal of Organic Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1134/s1070428024604746
- Primary Topic
- Chemical synthesis and pharmacological studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00