Pathological response guides adjuvant 5-fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) chemotherapy in surgically resected gastro-oesophageal cancer (SPACE-FLOT): international cohort study
Pathological response to neoadjuvant FLOT may guide the use of adjuvant FLOT, enabling personalized approaches to treatment.
Authors
- Geraldine Ooi (ORCID: https://orcid.org/0000-0002-4540-408X)
- Jacky Lu (ORCID: https://orcid.org/0000-0001-8737-220X)
- David I. Watson (ORCID: https://orcid.org/0000-0002-7683-2693)
- Vijayaragavan Muralidharan
- Mei Sien Liew
- Amy C. Edmondson (ORCID: https://orcid.org/0000-0003-4409-913X)
- Rod Jacobs
- Suraj Surendran (ORCID: https://orcid.org/0000-0003-4836-9432)
- Ryan Newbold (ORCID: https://orcid.org/0000-0003-1384-5910)
- Deanna Lee
- Joshua N. Hammerschlag (ORCID: https://orcid.org/0000-0001-8912-308X)
- Joseph Jaya (ORCID: https://orcid.org/0000-0003-0453-538X)
- James M. Wilkins (ORCID: https://orcid.org/0000-0002-0760-8532)
- Harsh Kanhere (ORCID: https://orcid.org/0000-0002-0181-6461)
- Amy Crowe (ORCID: https://orcid.org/0000-0003-4357-1236)
- Alain Nguyen (ORCID: https://orcid.org/0000-0002-1358-4952)
- Marek Bąk (ORCID: https://orcid.org/0000-0001-6940-8440)
- Paolo De Martini (ORCID: https://orcid.org/0000-0002-2395-2237)
- Thomas Murphy
- Niall Dempster (ORCID: https://orcid.org/0000-0001-8365-2028)
- Matthew Read (ORCID: https://orcid.org/0000-0001-7178-1973)
- Krinal Mori (ORCID: https://orcid.org/0000-0001-8513-2130)
- Mark I. van Berge Henegouwen (ORCID: https://orcid.org/0000-0001-8689-3134)
- Guillaume Piessen (ORCID: https://orcid.org/0000-0001-8243-8310)
- Felicia C. Huynh
- Nicholas Evennett
- B. Mark Smithers (ORCID: https://orcid.org/0000-0002-8333-8685)
- Sam Alhayo (ORCID: https://orcid.org/0000-0003-3295-8566)
- David S. Liu (ORCID: https://orcid.org/0000-0001-8936-4123)
- Sivakumar Gananadha (ORCID: https://orcid.org/0000-0003-4603-089X)
- Brendan Desmond (ORCID: https://orcid.org/0000-0003-2717-5583)
- Aya Siblini
- Kunal Bhanot (ORCID: https://orcid.org/0000-0002-4040-7126)
- Lynn Chong (ORCID: https://orcid.org/0000-0002-2595-958X)
- Michael Bozin (ORCID: https://orcid.org/0000-0001-8483-0674)
- Adam John Frankel (ORCID: https://orcid.org/0000-0002-5198-7664)
- Ahmad Aly (ORCID: https://orcid.org/0000-0001-8181-7386)
- Kevin Lah (ORCID: https://orcid.org/0000-0003-0150-6241)
- Margaret M Lee
- Bas P. L. Wijnhoven (ORCID: https://orcid.org/0000-0003-4738-3697)
- Mo Ballal
- David Williams (ORCID: https://orcid.org/0000-0002-8209-6899)
- Chao Cheng (ORCID: https://orcid.org/0000-0003-3180-7854)
- Swathikan Chidambaram (ORCID: https://orcid.org/0000-0002-4009-3243)
- Joe Wei (ORCID: https://orcid.org/0000-0003-1944-1079)
- Monica Gualtierotti (ORCID: https://orcid.org/0000-0002-4567-6587)
- Rukshan Ranjan
- Sarah A. Martin (ORCID: https://orcid.org/0000-0003-3321-6601)
- Ben Gibbons
- Suzanne Sarah Gisbertz (ORCID: https://orcid.org/0000-0001-9655-7601)
- Siang Wei Gan (ORCID: https://orcid.org/0000-0002-4718-7904)
- Enoch Wong (ORCID: https://orcid.org/0000-0002-2983-4768)
- Kyungchul Kim
- Inian Samarasam (ORCID: https://orcid.org/0000-0002-7800-9318)
- Ashray Rajagopalan (ORCID: https://orcid.org/0000-0002-5421-7120)
- Lorenzo Ferri (ORCID: https://orcid.org/0000-0003-3275-2584)
- David Lok Hang Chan (ORCID: https://orcid.org/0000-0002-7773-3144)
- Sotiris Mastoridis (ORCID: https://orcid.org/0000-0001-7689-2330)
- Aadil Rahim (ORCID: https://orcid.org/0000-0001-7192-2019)
- James Walmsley (ORCID: https://orcid.org/0000-0002-4168-5072)
- Stephen Barnett (ORCID: https://orcid.org/0000-0002-8350-2860)
- Su Kah Goh (ORCID: https://orcid.org/0000-0002-6684-2521)
- Michalis Koullouros (ORCID: https://orcid.org/0000-0001-6688-7634)
- Jonathan Yeung (ORCID: https://orcid.org/0000-0001-5759-3028)
- Jurstine Daruwalla (ORCID: https://orcid.org/0000-0002-2615-1750)
- Garett Smith
- Richard van Hillegersberg
- Helen Jaretzke
- Yat Cheung Chung
- Emily Moran (ORCID: https://orcid.org/0000-0003-4624-1910)
- Ramesh Gurunathan
- Sean R. Stevens
- Kammy Keywani (ORCID: https://orcid.org/0000-0002-4027-8715)
- Robert Bohmer
- Darren Wong (ORCID: https://orcid.org/0000-0003-1490-0547)
- Neil D. Merrett (ORCID: https://orcid.org/0000-0002-8370-0293)
- Janine Thomas
- Louise Jackett (ORCID: https://orcid.org/0000-0003-2792-6199)
- Jelle P. Ruurda
- Jonathan Tiong (ORCID: https://orcid.org/0000-0003-2621-2530)
- Ewen A. Griffiths (ORCID: https://orcid.org/0000-0001-6630-3547)
- Wael Jamel (ORCID: https://orcid.org/0000-0003-0117-0071)
- Katie L. Whytock (ORCID: https://orcid.org/0000-0003-3486-9452)
- Fredrik Klevebro (ORCID: https://orcid.org/0000-0002-1695-4103)
- Shantanu Joglekar (ORCID: https://orcid.org/0000-0003-4041-7620)
- Jenny Choi
- Jason Robertson
- Joel D’Souza (ORCID: https://orcid.org/0000-0003-2570-6336)
- Iain G. Thomson (ORCID: https://orcid.org/0000-0001-9681-1315)
- M H Pang (ORCID: https://orcid.org/0009-0005-8146-4900)
- A. Gower
- Tim Bright (ORCID: https://orcid.org/0000-0003-3700-5262)
- Sam Owen-Smith
- Brian C. Trainor (ORCID: https://orcid.org/0000-0002-4627-5478)
- Yosuke Okamura (ORCID: https://orcid.org/0000-0002-8811-9377)
- Claire L. Donohoe (ORCID: https://orcid.org/0000-0001-9373-2662)
- Pietro Maria Lombardi (ORCID: https://orcid.org/0000-0002-2633-7977)
- Sharon Pattison (ORCID: https://orcid.org/0000-0003-2188-3423)
- Rosemary Ho (ORCID: https://orcid.org/0000-0003-1882-5628)
- Areeb Mian (ORCID: https://orcid.org/0000-0002-4035-4052)
- Eugene Kwong Fei Leong (ORCID: https://orcid.org/0000-0001-6926-220X)
- M. Soo
- Andrew P. Barbour (ORCID: https://orcid.org/0000-0002-0991-7662)
- Saania Peeroo (ORCID: https://orcid.org/0000-0002-0687-7036)
- Alexander W. Phillips (ORCID: https://orcid.org/0000-0001-9826-3949)
- D. C. Gotley (ORCID: https://orcid.org/0000-0002-8604-253X)
- Eve Hopping (ORCID: https://orcid.org/0000-0002-6165-0264)
- Jeremy Granger
- Negine Paul (ORCID: https://orcid.org/0000-0003-4397-1985)
- Magnus Nilsson (ORCID: https://orcid.org/0000-0002-6215-8132)
- Yi-Tzu Linda Lin
- S. Phillips (ORCID: https://orcid.org/0000-0002-2290-1454)
- Aaditya Narendra (ORCID: https://orcid.org/0000-0002-6076-1077)
- Pooja Prasad (ORCID: https://orcid.org/0000-0002-6399-7835)
- Niall C. Tebbutt (ORCID: https://orcid.org/0000-0003-2613-5168)
- Charlène van der Zijden
- Jimmy Bok Yan So (ORCID: https://orcid.org/0000-0002-9772-7905)
- Yick Ho Lam (ORCID: https://orcid.org/0000-0002-6924-4201)
- Lauren R. Kennedy-Metz (ORCID: https://orcid.org/0000-0002-2696-3943)
- Daryl Kai Ann Chia (ORCID: https://orcid.org/0000-0001-9936-1225)
- Justine Lerooy
- Vipin Khandelwal (ORCID: https://orcid.org/0000-0002-0797-7055)
- Lianne Triemstra (ORCID: https://orcid.org/0000-0002-7057-0274)
- Mohammed Al Azzawi (ORCID: https://orcid.org/0000-0001-5372-4473)
- Chun Chan (ORCID: https://orcid.org/0000-0002-3705-1835)
- Tvisha Ijner
- Zhen Zhou (ORCID: https://orcid.org/0000-0003-0230-9688)
- Eunice Lee (ORCID: https://orcid.org/0000-0001-6225-0249)
- Steven Tran
- Yahya Al-Habbal
- Mary Ann Johnson (ORCID: https://orcid.org/0000-0002-8776-1202)
- Giovanni Ferrari (ORCID: https://orcid.org/0000-0002-5405-9046)
- Sheraz Markar (ORCID: https://orcid.org/0000-0002-4040-5681)
- Douglas Wood (ORCID: https://orcid.org/0000-0003-4128-6562)
- Christina McVeay
- Cuong Duong
- Chon Hann Liew
- Frances Allison
- Andrew D MacCormick
- Val Usatoff
- Alexandra Gordon
- Shaun Chew
- Michael Michael
- Riteshkumar Patel
- BS Ko
- David Chan
- Simon Bann
- Aldenb Lorenzo
- Girish Pande
- Katheryn Hall
- F H
- John Reynolds
- James Tan
- Evin Doyle
- Nicholas Eikelboom
- Rachel McLay-Barnes
- Frida Bushati
Publication Details
- Journal
- British journal of surgery
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1093/bjs/znaf056
- Citations
- 7
- Primary Topic
- Gastric Cancer Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 10.63
Funders
- Royal Australasian College of Surgeons
- Peter MacCallum Cancer Centre