Aerosolized delivery resulting in high polymyxin B concentration levels in epithelial lining fluid ensures efficacy in ventilator-associated pneumonia
This study presented polymyxin B concentrations in ELF following aerosolized delivery, supporting its clinical use from a PK/PD perspective. Following combined aerosol and intravenous administration, polymyxin B achieved notably higher concentrations in ELF than those observed in plasma.
Authors
- Xiaofen Liu (ORCID: https://orcid.org/0000-0002-5526-1502)
- Xingyi Qu
- Beining Guo (ORCID: https://orcid.org/0000-0003-1806-454X)
- Chuhan Zhang (ORCID: https://orcid.org/0000-0001-8466-2797)
- Jing Zhang (ORCID: https://orcid.org/0000-0003-2966-9149)
- Xin Li (ORCID: https://orcid.org/0000-0002-7414-5734)
- Yu Wang (ORCID: https://orcid.org/0000-0002-7512-0002)
- Jin Hu (ORCID: https://orcid.org/0000-0001-9160-6400)
- Meihua Wang (ORCID: https://orcid.org/0000-0002-3597-6631)
- Yaxin Fan (ORCID: https://orcid.org/0000-0002-1403-8072)
- Chenxue Guo
- Hailan Wu
- Lei Yang (ORCID: https://orcid.org/0000-0002-3494-8161)
Institutions
- Fudan University (CN)
- National Health and Family Planning Commission (CN)
- National Clinical Research (US)
- Huashan Hospital (CN)
Publication Details
- Journal
- JAC-Antimicrobial Resistance
- Published
- 2025-03-04
- DOI
- https://doi.org/10.1093/jacamr/dlaf023
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality