Characterization of Canadian Neisseria meningitidis serogroup B isolates and factor-H binding protein expression, data from the Canadian Immunization Monitoring Program Active (IMPACT), 2013–2020
CC-269 and CC-41/44 predominated in 2013-2020. Notably, peptide 15, the most prevalent until 2015, declined significantly thereafter. The majority of isolates expressed fHbp at a level associated with vaccine-induced protection. A wider age authorization for the vaccine may result in increased prevention of NmB disease.
Authors
- Shaun K. Morris (ORCID: https://orcid.org/0000-0001-9809-0822)
- S. A. Clark (ORCID: https://orcid.org/0000-0002-4916-3623)
- Julie A. Bettinger (ORCID: https://orcid.org/0000-0002-2118-4174)
- Raymond S. W. Tsang (ORCID: https://orcid.org/0000-0003-4062-4902)
- Scott A. Halperin (ORCID: https://orcid.org/0000-0003-0525-589X)
- Manish Sadarangani (ORCID: https://orcid.org/0000-0002-9985-6452)
- Nicole Le Saux (ORCID: https://orcid.org/0000-0002-0817-3526)
- Ray Borrow
- Taj Jadavji
- Kevin Meesters
Institutions
- Dalhousie University (CA)
- University of Calgary (CA)
- Public Health Agency of Canada (CA)
- University of Toronto (CA)
- Children's Hospital of Eastern Ontario (CA)
- Manchester Royal Infirmary (GB)
- Nova Scotia Health Authority (CA)
- BC Children's Hospital (CA)
Publication Details
- Journal
- Vaccine
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1016/j.vaccine.2025.127030
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 0.00