USE OF THE PROBIOTIC STREPTOCOCCUS SALIVARIUS K12 TO CORRECT THE ORAL MICROBIOME IN CHILDREN WITH OSTEOGENESIS IMPERFECTA

Topicality. The oral microbiome is vital for a child's health, as it is an important regulatory mechanism of homeostasis. Disruption of the balance in this ecological niche, caused by such a serious systemic disease as osteogenesis imperfecta, can lead to some dental diseases. Finding ways to correct oral dysbiosis and influence cariogenic and periodontal pathogenic bacteria in children with osteogenesis imperfecta is a pressing problem.The study aims to determine the effectiveness of the probiotic strain Streptococcus salivarius K12 in correcting the oral microbiome in children with osteogenesis imperfecta.Materials and methods. The study was conducted with the participation of children aged 2 to 17 years with a diagnosis of osteogenesis imperfecta type III, in whom an increased level of oral cavity contamination with cariogenic bacteria Streptococcus mutans and periodontal pathogens Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Treponema denticola, Bacteroides forsythus, Prevotella intermedia was determined. The probiotic strain Streptococcus salivarius K12 was used as a drug to correct the oral microbiome.Results. In all children with osteogenesis imperfecta, before the start of taking the probiotic strain Streptococcus salivarius K12, a borderline to high level of Streptococcus mutans contamination and the presence of first-order periodontal pathogens were detected, mainly in the form of monocultures in preclinical concentrations, which, against the background of low collagen quality in children with osteogenesis imperfecta, indicates a fairly high risk of developing caries and periodontal tissue diseases. One month after discontinuation of the probiotic strain Streptococcus salivarius K12, the level of Streptococcus mutans contamination in all children in both age groups decreased to normal levels, and the first-order periodontal pathogen Actinobacillus actinomycetemcomitans was detected in preclinical concentrations in one young child.