Contribution of Body Fat to the Pathogenesis of Cancer

The pathogenesis of cancer has been significantly influenced by body fat, which has the capacity to affect a variety of biological processes. Chronic inflammation and insulin resistance are known to be exacerbated by excess body fat, particularly visceral adipose tissue, which can establish an optimal microenvironment for tumor cell proliferation and progression. Adipocytes generate hormones and cytokines that can induce cancer cell proliferation, angiogenesis, and metastasis. Furthermore, adipose tissue serves as a storage facility for environmental toxins and carcinogens, which may be released into the bloodstream during periods of metabolic duress or weight loss. Additionally, obesity-induced modifications in the metabolism of adipose tissue can result in the dysregulation of lipid signaling pathways, which in turn induces tumorigenesis.