Approaches to Timescale Choice in Cognitive Aging Research and Potential Implications for Estimated Exposure Effects: Coordinated Analyses in 10 Cohorts of Older Adults
Timescale was largely inconsequential for estimated effects of APOE genotype, but yielded differences in estimated diabetes effects, raising questions about the appropriate scale. The current age scale may be problematic because diabetes was measured heterogeneously in age across individuals, a common issue in aging cohorts. Our work demonstrates approaches to evaluate alternative timescales, including in multicohort analyses, and highlights potential implications for estimated exposure effects on cognitive change.
Authors
- Susan M. Resnick (ORCID: https://orcid.org/0000-0003-1115-7145)
- Phillip H Hwang (ORCID: https://orcid.org/0000-0001-6780-6808)
- Mateo Farina (ORCID: https://orcid.org/0000-0002-0765-6550)
- Alexandra J. Weigand (ORCID: https://orcid.org/0000-0002-7931-1383)
- Katrina Kezios (ORCID: https://orcid.org/0000-0001-7115-032X)
- Terry M. Therneau (ORCID: https://orcid.org/0000-0003-1490-6711)
- Alden L. Gross (ORCID: https://orcid.org/0000-0002-4678-0562)
- Elizabeth Rose Mayeda (ORCID: https://orcid.org/0000-0002-6326-0163)
- Kendra D. Sims (ORCID: https://orcid.org/0000-0002-6740-3002)
- Catherine Helmer (ORCID: https://orcid.org/0000-0002-5169-7421)
- Crystal Shaw (ORCID: https://orcid.org/0000-0001-6349-072X)
- Linda K. McEvoy (ORCID: https://orcid.org/0000-0003-4583-7798)
- Laura E. Gibbons (ORCID: https://orcid.org/0000-0001-5054-2543)
- Colin Louis Masters (ORCID: https://orcid.org/0000-0003-3072-7940)
- Jennifer Weuve (ORCID: https://orcid.org/0000-0003-0922-0256)
- Paul K. Crane (ORCID: https://orcid.org/0000-0003-4278-7465)
- Justina Avila‐Rieger (ORCID: https://orcid.org/0000-0001-7147-5829)
- Cécile Proust‐Lima (ORCID: https://orcid.org/0000-0002-9884-955X)
- Anaïs Rouanet (ORCID: https://orcid.org/0000-0001-7525-218X)
- Eleanor Hayes‐Larson (ORCID: https://orcid.org/0000-0001-8299-2389)
- Ruijia Chen (ORCID: https://orcid.org/0000-0002-2759-9290)
- Paul T. Maruff (ORCID: https://orcid.org/0000-0002-6947-9537)
- Jet M. J. Vonk (ORCID: https://orcid.org/0000-0002-1808-8843)
- Jennifer J. Manly (ORCID: https://orcid.org/0000-0002-9481-7497)
- Brandon S. Klinedinst (ORCID: https://orcid.org/0000-0003-2697-1852)
- Ryan M. Andrews (ORCID: https://orcid.org/0000-0002-7750-2397)
- Emma L. Nichols (ORCID: https://orcid.org/0000-0002-9005-3872)
- Indira C. Turney (ORCID: https://orcid.org/0000-0002-5912-1953)
- Vincent Bouteloup (ORCID: https://orcid.org/0009-0008-9956-862X)
- Jesse Mez (ORCID: https://orcid.org/0000-0003-1438-5442)
- Ariane Bercu
- Jingxuan Wang (ORCID: https://orcid.org/0000-0003-0380-6352)
- Kumar B. Rajan (ORCID: https://orcid.org/0000-0001-7685-2101)
- John C. Morris
- Ronald C. Petersen
- Marilyn Albert
Institutions
- Boston University (US)
- University of Southern California (US)
- Amgen (United States) (US)
- Johns Hopkins University (US)
- Kaiser Permanente Washington Health Research Institute (US)
- Université de Bordeaux (FR)
- Inserm (FR)
- University of San Diego (US)
- The University of Melbourne (AU)
- University of California, San Francisco (US)
- University of Washington (US)
- Washington University in St. Louis (US)
- Florey Institute of Neuroscience and Mental Health (AU)
- San Diego State University (US)
- Columbia University Irving Medical Center (US)
- UCLA Health (US)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- University Memory and Aging Center (US)
- Bordeaux Population Health (FR)
- Mayo Clinic in Arizona (US)
- Institute on Aging (US)
- National Institute on Aging (US)
- Mayo Clinic in Florida (US)
- Rush University (US)
- Columbia University (US)
- The University of Texas at Austin (US)
Publication Details
- Journal
- Epidemiology
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1097/ede.0000000000001859
- Citations
- 3
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 4.41