(±)‐Guignarenone D: First Total Synthesis and Its Glucose Uptake Activity
Abstract The synthesis of (±)‐guignarenone D was achieved for the first time on a gram scale through a nine‐step reaction sequence. A pivotal step in this process involved cyclization using NaH, and thereby retro‐aldol was inhibited. Its activity promoting glucose uptake was also tested.
Authors
- Hong‐Bo Qin (ORCID: https://orcid.org/0000-0003-2603-9520)
- Wenyong Xiong (ORCID: https://orcid.org/0000-0001-9174-3667)
- Yuan Sun (ORCID: https://orcid.org/0000-0001-8444-2129)
- Yifeng He (ORCID: https://orcid.org/0000-0002-0786-945X)
- Tao Chen
- Cheng Zhang (ORCID: https://orcid.org/0000-0001-7255-2179)
- Zhao-Nan Cai
Institutions
- Minzu University of China (CN)
- Yunnan University (CN)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1002/ajoc.202500080
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00