Impact of CYP19A1 genetic variations on polycystic ovary syndrome: findings from a case-control study
Our study demonstrates that the CYP19A1 rs2236722 polymorphism significantly correlates with PCOS risk, although rs700519 showed no significant association. The findings suggest that altered aromatase activity linked to rs2236722 may contribute to the hyperandrogenic phenotype observed in PCOS patients. These results enhance our understanding of the genetic basis of PCOS and may have implications for personalized treatment approaches.
Authors
- Rushikesh Joshi (ORCID: https://orcid.org/0000-0003-3772-5569)
- Naresh C. Laddha
- Mala Singh (ORCID: https://orcid.org/0000-0003-4506-5118)
- Hiral Chaudhary (ORCID: https://orcid.org/0000-0001-7864-981X)
- Jalpa Patel (ORCID: https://orcid.org/0000-0002-4727-7571)
- Parashar J. Nanavati
- Nayan Jain (ORCID: https://orcid.org/0000-0001-9458-6927)
- Sonal Panchal
Institutions
- Gujarat University (IN)
- Physical Research Laboratory (IN)
- Gujarat Cancer & Research Institute (IN)
- Ahmedabad Civil Hospital (IN)
- Stavya Spine Hospital & Research Institute (IN)
Publication Details
- Journal
- F&S Science
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1016/j.xfss.2025.03.005
- Citations
- 5
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 8.49