Transcriptional Co‐Activator With PDZ Binding Motif (TAZ) Inhibits Dexamethasone‐Induced Muscle Atrophy via mTOR Signalling
Our results demonstrate a novel regulatory mechanism of dexamethasone-induced muscle atrophy by TAZ, suggesting that stabilisation of TAZ in muscle cells ameliorates the muscle atrophy. These results suggest that TAZ may be a drug target for the dexamethasone-induced muscle atrophy.
Authors
- Gi Don Yoo (ORCID: https://orcid.org/0000-0003-1191-0547)
- Ho Taek Oh
- Mi Ran Byun
- Jeong‐Ho Hong
- J S Park
- Eun Sook Hwang
- Kyung Min Kim
- Hyejin Yang (ORCID: https://orcid.org/0000-0002-5238-7820)
- Woong Heo
- Suh Jin Yoon
- Youjin Do
Institutions
- Ewha Womans University (KR)
- Korea University (KR)
- Daegu Catholic University (KR)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-03-30
- DOI
- https://doi.org/10.1002/jcsm.13790
- Citations
- 2
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 2.30
Funders
- National Research Foundation
- Korea University
- National Research Foundation of Korea