Pregnancy Outcomes in Women With Primary Adrenal Insufficiency: Data From a Multicentre Cohort Study
Whilst the obstetric outcome of pregnancy with PAI is generally favourable, there are high rates of caesarean birth and prematurity. A high number of women experienced adrenal crisis and further exploration is warranted. Recommendations regarding third trimester increases in hydrocortisone need consideration and potentially strengthening, in light of further evidence. Pregnant women with adrenal insufficiency should carry an NHS steroid warning card; this should be reinforced both by endocrine and obstetric teams because of the increased risk of life-threatening adrenal crisis.
Authors
- Melanie Nana (ORCID: https://orcid.org/0000-0002-7908-8986)
- Julia Zöllner (ORCID: https://orcid.org/0000-0002-9072-9131)
- Miles Levy (ORCID: https://orcid.org/0000-0001-7256-7880)
- Shabana Ashiq
- F G Dunn
- Francesca Neuberger (ORCID: https://orcid.org/0000-0002-5630-6960)
- Fionnuala Mary McAuliffe (ORCID: https://orcid.org/0000-0002-3477-6494)
- Aarthi Mohan (ORCID: https://orcid.org/0000-0003-2556-9730)
- Philip J. Steer (ORCID: https://orcid.org/0000-0002-6119-5265)
- Katarzyna Gajewska‐Knapik (ORCID: https://orcid.org/0000-0002-6229-6551)
- Christine Newman (ORCID: https://orcid.org/0000-0003-2387-4109)
- Masato Ahsan (ORCID: https://orcid.org/0000-0001-8127-2101)
- Catherine Williamson (ORCID: https://orcid.org/0000-0002-6226-7611)
- Tara Lee (ORCID: https://orcid.org/0000-0001-6591-6421)
- Linden Stocker (ORCID: https://orcid.org/0000-0002-0930-1673)
- Gillian A. Corbett (ORCID: https://orcid.org/0000-0003-0378-8297)
- Hsu Phern Chong (ORCID: https://orcid.org/0000-0002-4662-3882)
- Catherine Napier
- Bijay Vaidya (ORCID: https://orcid.org/0000-0002-2223-0494)
- Clare Mumby
- Matthew Cauldwell (ORCID: https://orcid.org/0000-0003-2366-3133)
- Hassan Shehata (ORCID: https://orcid.org/0000-0001-9968-8391)
- Amanda Ali (ORCID: https://orcid.org/0000-0002-3698-1571)
- Helen Turner (ORCID: https://orcid.org/0000-0002-9659-1989)
- Jeremy Tomlinson
- Kate Wiles (ORCID: https://orcid.org/0000-0003-0617-8144)
- Therese Kinsella
- Rebecca Ashworth
- Adam D Jakes (ORCID: https://orcid.org/0000-0003-0943-8618)
- Amelia Shard (ORCID: https://orcid.org/0009-0002-1156-3522)
- Adele Beck
- Amanda Hill (ORCID: https://orcid.org/0009-0005-1531-3215)
- Lucy MacKiliop
- Emma Ward
- David G. McLaren
- Tabitha Oosterhouse
- Deena Basha
Institutions
- University College Dublin (IE)
- Betsi Cadwaladr University Health Board (GB)
- University College Hospital (GB)
- North Bristol NHS Trust (GB)
- University of Liverpool (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Barts Health NHS Trust (GB)
- University of Exeter (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- Norfolk and Norwich University Hospital (GB)
- University Hospitals Bristol NHS Foundation Trust (GB)
- Rosie Hospital (GB)
- St Helier Hospital (GB)
- University Hospitals of Leicester NHS Trust (GB)
- University of Oxford (GB)
- St Mary's Hospital (GB)
- Liverpool Women's Hospital (GB)
- St George's Hospital (GB)
- Newcastle upon Tyne Hospital (GB)
- Oxford Centre for Diabetes, Endocrinology and Metabolism (GB)
- St Michael's Hospital (GB)
- National Maternity Hospital (IE)
- Chelsea and Westminster Hospital (GB)
- St Michael’s Hospital (GB)
- Kingston Hospital (GB)
- Oxford University Hospitals NHS Trust (GB)
- Exeter Hospital (GB)
- Birmingham Women’s and Children’s NHS Foundation Trust (GB)
- Addenbrooke's Hospital (GB)
- Trials Methodology Research Network (IE)
- St Michaels Hospital (GB)
- St. Mary's Hospital (GB)
- University College London (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- BJOG An International Journal of Obstetrics & Gynaecology
- Published
- 2025-03-30
- DOI
- https://doi.org/10.1111/1471-0528.18143
- Citations
- 2
- Primary Topic
- Adrenal Hormones and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.59
Funders
- Society for Endocrinology