Inducing Ischemic Stroke via Middle Cerebral Artery Occlusion Using a Thread Bolt

Source: Liu, P., et al., A Preclinical Model to Assess Brain Recovery After Acute Stroke in Rats. J. Vis. Exp. (2019) This video demonstrates the process of inducing ischemic stroke in a rat model by occluding the middle cerebral artery (MCA) using a thread bolt. The procedure involves ligating the carotid arteries, inserting a thread bolt into the external carotid artery, and blocking blood flow from the MCA to the brain, leading to neuronal death and mimicking an ischemic stroke.