Catalytic Decarbonylative Functionalization of C–H Bonds with Carboxylic Acids

Abstract Within the past decades, the potential of transition-metal-catalyzed cross-coupling reactions using carboxylic acids as the coupling partners has been subjected to extensive exploitation because of the natural abundance, ready availability, nontoxicity, stability, structural diversity, and low cost of carboxylic acids. Notably, recent years have witnessed intense research interest in the combination of decarbonylation of carboxylic acids with direct C–H bond functionalization in the presence of transition-metal catalysts for the formation of various C–C bonds with release of CO. The approach presents a powerful alternative to the existing repertoire of transition-metal-catalyzed direct functionalization of C–H bonds via C–C bond formation. In this Account, we highlight our recent achievements in the development of decarbonylative functionalization of C–H bonds with carboxylic acids under transition-metal catalysis. 1 Introduction 2 Arylation with Aryl Carboxylic Acids 3 Alkenylation with Alkenyl Carboxylic Acids 4 Alkylation with Alkyl Carboxylic Acids 5 Conclusion and Outlook