High dose acetaminophen re-polarizes CD11b+ cells in the tumor microenvironment towards an activated macrophage phenotype
The present study demonstrates profound AAP-induced changes in the tumor immune microenvironment including the differentiation of CD11b+ cells towards an activated "M1" macrophage phenotype.
Authors
- Bhaumik B. Patel (ORCID: https://orcid.org/0000-0002-6618-4004)
- Madison Isbell
- Madelyn R. Lorenz
- Lauren May (ORCID: https://orcid.org/0000-0003-4422-7074)
- Allyn Bryan (ORCID: https://orcid.org/0000-0002-3269-6781)
- Pavani Pingali
- Alex Neuwelt
- Rebecca Martin (ORCID: https://orcid.org/0000-0001-9948-5463)
- Jennifer E. Koblinski (ORCID: https://orcid.org/0000-0002-7156-2030)
- Won Sok Lee (ORCID: https://orcid.org/0000-0002-0722-669X)
- Adam Khader (ORCID: https://orcid.org/0000-0002-9276-132X)
- Joseph W. Landry (ORCID: https://orcid.org/0000-0002-9118-4081)
- Andrea Galabow
- Syed Shah (ORCID: https://orcid.org/0009-0003-4083-0535)
Institutions
- University of Richmond (US)
- Virginia Commonwealth University (US)
- Department of Veterans Affairs (AU)
Publication Details
- Journal
- Neoplasia
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1016/j.neo.2025.101155
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80