L-methionine promotes CD8+ T cells killing hepatocellular carcinoma by inhibiting NR1I2/PCSK9 signaling
This work demonstrates that L-methionine promotes CD8<sup>+</sup> T cell-mediated killing of hepatocellular carcinoma by inhibiting NR1I2/PCSK9 signaling. Our study introduces a novel and convenient approach to inhibit PCSK9 and provides a theoretical basis for the rational supplementation of L-methionine in liver cancer patients.
Authors
- Changpeng� Hu (ORCID: https://orcid.org/0000-0002-3033-4023)
- Ya‐Feng Liu (ORCID: https://orcid.org/0000-0002-9684-9150)
- Huyue Zhou
- Wuyi Liu (ORCID: https://orcid.org/0000-0002-3174-6492)
- Wenjing Lai
- Rong Zhang (ORCID: https://orcid.org/0000-0003-1188-0640)
- Guobing� Li (ORCID: https://orcid.org/0000-0003-4113-5641)
- Yue Yin
- Chengsha Yuan
Institutions
- Army Medical University (CN)
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Neoplasia
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1016/j.neo.2025.101160
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04