Transcriptional and cytokine signatures of Mycobacterium abscessus complex pulmonary disease during disease progression and treatment
These findings provide insights into the immune profiles of MABC-PD patients during disease progression and suggest that T cell-associated cytokines, such as IFNγ and IL17F, could serve as useful biomarkers for identifying those under watchful waiting or post-treatment who are at risk of disease progression, thereby aiding in more timely and targeted therapeutic interventions.
Authors
- Danny Jian Hang Tng (ORCID: https://orcid.org/0000-0003-4116-2797)
- Yi Hern Tan (ORCID: https://orcid.org/0000-0003-0559-2001)
- Jia Xin Yee (ORCID: https://orcid.org/0000-0001-9056-3621)
- Eng Eong Ooi (ORCID: https://orcid.org/0000-0002-0520-1544)
- Jenny G. Low (ORCID: https://orcid.org/0000-0002-3876-2209)
- Sarah Sim
- Ayesa Syenina (ORCID: https://orcid.org/0000-0003-0061-8401)
- Eugenia Z. Ong (ORCID: https://orcid.org/0000-0003-2187-7058)
- Valerie Chew (ORCID: https://orcid.org/0000-0002-5617-0936)
- Dorothy Hui Lin Ng (ORCID: https://orcid.org/0000-0003-0917-1474)
Institutions
- Singapore General Hospital (SG)
- SingHealth Duke-NUS Academic Medical Centre (SG)
- Duke-NUS Medical School (SG)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1371/journal.pntd.0012943
- Citations
- 3
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- SingHealth