Overexpression of tRNA m7G modification methyltransferase complex promotes the biosynthesis of triterpene in yeast
These findings indicate that tRNA m<sup>7</sup>G modification can regulate central metabolism and enhance terpenoid biosynthesis. This study provides new insights into RNA modifications as a potential metabolic engineering strategy for improving the production of high-value compounds.
Authors
- Mengyu Ma
- Zhengwei Tan (ORCID: https://orcid.org/0000-0002-7350-2234)
- Tianyue An (ORCID: https://orcid.org/0000-0002-7291-3752)
- Baochen Fan
- Xiqin Liang
- Jun Wang (ORCID: https://orcid.org/0000-0002-4606-5585)
- Guoli Wang (ORCID: https://orcid.org/0000-0002-0318-8905)
- Lei Li (ORCID: https://orcid.org/0000-0001-7187-4897)
- Huizhen Liang (ORCID: https://orcid.org/0000-0002-9709-0721)
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Henan Academy of Agricultural Sciences (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-03-31
- DOI
- https://doi.org/10.3389/fmicb.2025.1557443
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00