Laser technologies for joining biological tissue

Objective. Improving the effectiveness of surgical treatment for dental patients through the experimental development of a laser seam for soft tissues in the maxillofacial area using laser radiation and biopolymer. Materials and methods. The experimental research model was created on 8 laboratory rabbits of the Chinchilla breed. Linear wounds on the skin were made with a surgical scalpel No. 15C and sutured. All rabbits were divided into 3 research groups: group 1, wounds were sutured with Prolen 5.0 thread; group 2, the edges of the wounds were joined using laser tissue welding with a laser device with a wavelength of 970 nm and Bioadhesive No. 1 based on bovine serum albumin and indocyanine green; group 3, the edges of the wounds were joined using laser tissue welding with a laser device with a wavelength of 970 nm and Bioadhesive No. 2 based on bovine serum albumin, indocyanine green, and single-walled carbon nanotubes. In the postoperative period, the severity of edema, intensity of hyperemia, and the time of wound epithelialization were assessed on days 1, 3, 5, and 10 in points. Results. Experimental studies on rabbits in vivo showed that the best regeneration occurred when the edges of wounds were joined using laser skin welding with laser radiation and Biopreparation No. 2. In the postoperative period, there was minimal swelling and hyperemia, no suture dehiscence or tissue necrosis was observed, and earlier epithelialization and an aesthetic scar were noted. Conclusion. The use of laser radiation and biopreparations is a promising method for joining the edges of wounds on the skin, as it accelerates regeneration and forms an aesthetic scar.