Synthesis and Antiarrhythmic Activity of New 1,3,4-Oxadiazole Derivatives Containing a 1,4-Benzodioxane Fragment
The reaction of previously reported 4-(1,4-benzodioxan-6-yl)tetrahydro-2H-pyran-4-carbonyl chloride with hydrazine hydrate gave symmetrical diacylhydrazine which was cyclized to 2,5-bis[4-(1,4-benzodioxan-6-yl)tetrahydro-2H-pyran-4-yl]-1,3,4-oxadiazole by the action of phosphoryl chloride. Unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles were synthesized by the condensation of 4-(1,4-benzodioxan-6-yl)tetrahydro-2H-pyran-4-carbonyl chloride with various acid hydrazides, followed by cyclization of the resulting diacylhydrazines with phosphoryl chloride. The synthesized compounds were evaluated for their antiarrhythmic activity.
Authors
- S. O. Vardanyan (ORCID: https://orcid.org/0000-0003-4582-7629)
- H. А. Panosyan (ORCID: https://orcid.org/0000-0001-8311-6276)
- G. S. Mkrtchyan
- A. B. Sargsyan (ORCID: https://orcid.org/0000-0001-7115-9164)
- R. E. Muradyan (ORCID: https://orcid.org/0000-0002-4110-9454)
- А. А. Aghekyan (ORCID: https://orcid.org/0000-0001-6151-4951)
- H. E. Tumajyan (ORCID: https://orcid.org/0000-0003-2151-4767)
- A. S. Avagyan (ORCID: https://orcid.org/0000-0002-7148-3666)
Institutions
- Institute of Fine Organic Chemistry of Scientific - Technological Center of Organic and Pharmaceutical Chemistry (AM)
- National Academy of Sciences of Armenia (AM)
Publication Details
- Journal
- Russian Journal of Organic Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1134/s1070428024602966
- Citations
- 1
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.94