Types of effects of SARS-CoV-2 on the human body: from coagulopathy to cytokine storm

Review focuses on the clinical presentation and pathogenesis of COVID-19, particularly in the context of the interaction between SARS-CoV-2 virus and angiotensin-converting enzyme II (ACE-II), which plays a key role in viral entry into host cells. The article details the mechanisms underlying cytokine storm, coagulopathy and other important aspects of severe disease, including increased expression of pro-inflammatory cytokines and alterations in the haemostasis system. This article analyses the consequences of abnormal activation of the immune system leading to acute respiratory distress syndrome, disseminated intravascular coagulation and multi-organ failure. In addition, the role of anticoagulant therapy in the prevention and treatment of thrombotic complications is discussed. The study emphasises the need for an individual approach in the treatment and prevention of COVID-19 depending on the severity of the disease and other clinical parameters.

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Publication Details

Journal
Vrach
Published
2025-03-19
DOI
https://doi.org/10.29296/25877305-2025-03-02
Primary Topic
COVID-19 Clinical Research Studies
Type
article
Field-Weighted Citation Impact
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article

Types of effects of SARS-CoV-2 on the human body: from coagulopathy to cytokine storm

D.А. Kudlаy, Evgeny Pokushalov, Анатолий Ильич Хавкин, K. M. Nikolaychuk et al.
Vrach
COVID-19 Clinical Research Studies
article

Types of effects of SARS-CoV-2 on the human body: from coagulopathy to cytokine storm

D.А. Kudlаy, Evgeny Pokushalov, Анатолий Ильич Хавкин, K. M. Nikolaychuk, Д. В. Сергеев, D. A. Lukichev, Sophia Alexandrovna Yakovleva, E. E. Vergunova, A. S. Tumas, P. Ya. Platonova, Mariia Novikova, E. V. Shrayner
article en

Abstract

Review focuses on the clinical presentation and pathogenesis of COVID-19, particularly in the context of the interaction between SARS-CoV-2 virus and angiotensin-converting enzyme II (ACE-II), which plays a key role in viral entry into host cells. The article details the mechanisms underlying cytokine storm, coagulopathy and other important aspects of severe disease, including increased expression of pro-inflammatory cytokines and alterations in the haemostasis system. This article analyses the consequences of abnormal activation of the immune system leading to acute respiratory distress syndrome, disseminated intravascular coagulation and multi-organ failure. In addition, the role of anticoagulant therapy in the prevention and treatment of thrombotic complications is discussed. The study emphasises the need for an individual approach in the treatment and prevention of COVID-19 depending on the severity of the disease and other clinical parameters.

Vrach
Belgorod National Research University (RU), Sechenov University (RU), Novosibirsk State University (RU), Lomonosov Moscow State University (RU), Institute of Chemical Biology and Fundamental Medicine (RU), Novosibirsk Institute of Organic Chemistry (RU), Ministry of Health of the Russian Federation (RU), Siberian Branch of the Russian Academy of Sciences (RU), Medical Technologies (Czechia) (CZ)
Openalex Percentile: Top 91%
COVID-19 Clinical Research Studies
DOISourceOpenAlex
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