Deciphering the integrated immunogenomic landscape of colorectal cancer: insights from Mendelian randomization and immune-stratified molecular subtyping
Genetic interrogation delineated causal immunome-CRC relationships at single-cell resolution. Immune-stratified CRC subtyping stratified patient outcomes. GPD1L exhibited tumor-suppressive functions. Our findings establish an integrated immunogenomic framework elucidating CRC pathogenesis with implications for precision immunotherapies.
Authors
- Ke‐Jie He (ORCID: https://orcid.org/0000-0001-7406-6254)
- Guoyu Gong
Institutions
- Xiamen University (CN)
- Wenzhou Medical University (CN)
- Quzhou City People's Hospital (CN)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1186/s12876-025-03776-4
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Quzhou Municipal Science and Technology Bureau