Melatonin attenuates brain edema via the PI3K/Akt/Nrf2 pathway in rats with cerebral ischemia-reperfusion injury
Mel administration exerts neuroprotective effects against CIRI by mitigating brain edema through upregulating the PI3K/AKT/Nrf2 signaling pathway, and then attenuating brain damage in CIRI rats.
Authors
- Xiaoli Wu (ORCID: https://orcid.org/0000-0002-2523-7499)
- Xizhen Wang (ORCID: https://orcid.org/0000-0003-0993-1170)
- Fenghua Zhou (ORCID: https://orcid.org/0000-0002-6110-2196)
- Xin Wang (ORCID: https://orcid.org/0000-0001-8079-8638)
- Zhen Li (ORCID: https://orcid.org/0000-0001-8037-4245)
- Qi Wang (ORCID: https://orcid.org/0000-0001-8972-4758)
- Xiaoli Wang (ORCID: https://orcid.org/0000-0003-3334-6713)
- Yang Liu (ORCID: https://orcid.org/0000-0002-8831-0526)
- Xiaotian Gao (ORCID: https://orcid.org/0000-0002-2233-8200)
- Judy Pi
Institutions
- Weifang Medical University (CN)
- Weifang People's Hospital (CN)
Publication Details
- Journal
- Journal of Stroke and Cerebrovascular Diseases
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108299
- Citations
- 3
- Primary Topic
- Medicinal Plants and Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 2.42