Ammonia Suppresses the Antitumor Activity of Natural Killer Cells and T Cells by Decreasing Mature Perforin
Ammonia is elevated in the tumor microenvironment and functions as an immunoinhibitory metabolite in cancer by reducing perforin levels, inhibiting NK and T-cell-mediated immunity and limiting the efficacy of immunotherapies.
Authors
- Monika Granica (ORCID: https://orcid.org/0000-0001-8782-7139)
- Tomasz Węgierski (ORCID: https://orcid.org/0000-0003-2635-8580)
- Aleksandra Kusowska (ORCID: https://orcid.org/0000-0001-6808-9919)
- Spencer Moros
- Marcin Poręba (ORCID: https://orcid.org/0000-0002-0214-6252)
- Lea K. Picard (ORCID: https://orcid.org/0000-0002-3969-9061)
- Carsten Watzl (ORCID: https://orcid.org/0000-0001-5195-0995)
- Zofia Pilch (ORCID: https://orcid.org/0000-0002-8214-7158)
- Marta Miączyńska (ORCID: https://orcid.org/0000-0003-0031-5267)
- Stephen L. Hajduk
- Leyuan Ma (ORCID: https://orcid.org/0000-0002-0583-7470)
- Maria Łęcka (ORCID: https://orcid.org/0000-0001-8104-4803)
- Doris Urlaub
- Joanna Domagała
- Agnieszka Graczyk‐Jarzynka (ORCID: https://orcid.org/0000-0001-7980-0542)
- Marta Kłopotowska (ORCID: https://orcid.org/0000-0001-5450-531X)
- Paweł Kozłowski (ORCID: https://orcid.org/0000-0002-6543-7727)
- Kamil Jastrzębski (ORCID: https://orcid.org/0000-0001-6481-1759)
- Iwona Baranowska (ORCID: https://orcid.org/0000-0002-8680-4442)
- Katsiaryna Marhelava (ORCID: https://orcid.org/0000-0002-9422-5969)
- Magdalena Justyniarska (ORCID: https://orcid.org/0009-0002-4945-1403)
- Klaudyna Fidyt (ORCID: https://orcid.org/0000-0003-0568-4950)
- Marta Krawczyk (ORCID: https://orcid.org/0000-0001-9487-1744)
- Tomasz M. Grzywa (ORCID: https://orcid.org/0000-0002-1809-248X)
- Magdalena Winiarska (ORCID: https://orcid.org/0000-0001-5605-3329)
- Małgorzata Bobrowicz (ORCID: https://orcid.org/0000-0002-9078-5168)
- Alexandra Neeser
- Ryan Tannir
Institutions
- Wrocław University of Science and Technology (PL)
- Children's Hospital of Philadelphia (US)
- TU Dortmund University (DE)
- Medical University of Warsaw (PL)
- University of the Arts (US)
- California University of Pennsylvania (US)
- Josep Carreras Leukaemia Research Institute (ES)
- University Hospital of Zurich (CH)
- International Institute of Molecular and Cell Biology (PL)
- Holy Cross University (PL)
- Mossakowski Medical Research Institute, Polish Academy of Sciences (PL)
- Leibniz Research Centre for Working Environment and Human Factors (DE)
- AGH University of Krakow (PL)
- University of Pennsylvania (US)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1158/0008-5472.can-24-0749
- Citations
- 12
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 9.57