Synthesis and antitumor activity of bis-camptothecin ester of succinic acid
New succinic diester containing two residues of antitumor alkaloid camptothecin has been synthesized. Its cytotoxicity and effect on cell cycle and induction of apoptosis were explored using modern methods of flow cytometry, as well as <em>in vitro</em> studies of the inhibitory activity against human topoisomerase I.
Authors
- Vladimir Anatol'evich D'yakonov (ORCID: https://orcid.org/0000-0002-7787-5054)
- Usein Memetovich Dzhemilev (ORCID: https://orcid.org/0000-0002-7992-6337)
- Lilya Useinovna Dzhemileva (ORCID: https://orcid.org/0000-0003-3315-4746)
- Nuri M. Chobanov (ORCID: https://orcid.org/0000-0002-7816-8757)
- Konstantin O Vakhnin
Institutions
- N.D. Zelinsky Institute of Organic Chemistry (RU)
- Institute of Physiologically Active Compounds (RU)
Publication Details
- Journal
- Mendeleev Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.71267/mencom.7641
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Russian Science Foundation