Glycopolymer-<em>graft</em>-polypeptide copolymers as potential carriers for nucleic acids
Bioinspired copolymers consisting of a glycopolymer main chain grafted with polylysine were synthesized using metal-free click chemistry based on a 1,3-dipolar cycloaddition reaction involving strained cyclic alkyne. Poly(2-deoxy-2- methacrylamido-d-glucose)-<em>graft</em>-polylysine was efficiently complexed with a double-stranded oligonucleotide duplex. The cytotoxicity of the polyplex was lower than that of the free copolymer.
Authors
- Sergey Vladislavovich Gladnev (ORCID: https://orcid.org/0000-0003-2009-6372)
- M. L. Levit (ORCID: https://orcid.org/0000-0002-2136-1329)
- Tatiana Tennikova (ORCID: https://orcid.org/0000-0002-9029-2056)
- Evgenia Korzhikova‐Vlakh (ORCID: https://orcid.org/0000-0002-2530-7709)
Institutions
- St Petersburg University (RU)
- Kurchatov Institute (RU)
- Institute of Macromolecular Compounds (RU)
- Petersburg Nuclear Physics Institute (RU)
Publication Details
- Journal
- Mendeleev Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.71267/mencom.7606
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Russian Science Foundation