Novel platinum(IV) prodrugs with tetraacetylriboflavin axial ligand possessing enhanced light-induced toxicity
Novel triple-action photoactivatable Pt<sup>IV</sup> prodrugs were obtained by modification of Riboplatin, a cisplatin-based prodrug bearing tetraacetylriboflavin in axial position. The modification involved incorporation of either Naproxen or albumin vector maleimide residues onto the second axial position of Riboplatin. The Pt<sup>IV</sup> prodrugs thus obtained possess improved pharmacokinetic, biological and photoactivating properties.
Authors
- Elena Kimovna Beloglazkina (ORCID: https://orcid.org/0000-0001-6796-8241)
- Dmitrii M. Mazur (ORCID: https://orcid.org/0000-0002-9780-1490)
- Roman Akasov (ORCID: https://orcid.org/0000-0001-6486-8114)
- Olga Olegovna Krasnovskaya (ORCID: https://orcid.org/0000-0002-4948-2747)
- Yuri K. Grishin (ORCID: https://orcid.org/0000-0001-7709-5245)
- Daniil V. Spector (ORCID: https://orcid.org/0000-0002-2726-2671)
- Vitaly A. Roznyatovsky
Institutions
- Moscow State Pedagogical University (RU)
- Sechenov University (RU)
- Lomonosov Moscow State University (RU)
Publication Details
- Journal
- Mendeleev Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.71267/mencom.7643
- Citations
- 2
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Russian Science Foundation