Diaryl α-nitrostilbenes as nitro-substituted analogues of combretastatins: synthesis and biological evaluation in the sea urchin embryo model
A series of nitro analogues of potent antimitotic combretastatin A-4 (diaryl α-nitrostilbenes, DNSs) was synthesized by the Knoevenagel condensation of arylnitromethanes with methylamine Schiff bases of benzaldehydes. The obtained stilbenes featured only <em>cis</em>-diaryl topology irrespective of substitution pattern in the aryl fragments. The evaluation on a sea urchin embryo model suggested that DNSs exhibited both antitubulin and tubulin-unrelated effects similar to those of corresponding monoaryl nitrostyrenes.
Authors
- Ivan A. Koblov
- Victor N. Khrustalev (ORCID: https://orcid.org/0000-0001-8806-2975)
- Anna S. Maksimenko (ORCID: https://orcid.org/0000-0001-6945-2046)
- В. П. Кислый (ORCID: https://orcid.org/0000-0002-6885-4120)
- A. V. Samet (ORCID: https://orcid.org/0000-0002-0100-085X)
- Aida I. Samigullina (ORCID: https://orcid.org/0000-0002-6791-9973)
- Nikita A. Kuznetsov (ORCID: https://orcid.org/0000-0002-4016-198X)
- Marina N. Semenova (ORCID: https://orcid.org/0000-0001-7656-9023)
- Victor V. Semenov
- Karim Narimanovich Alisultanov
Institutions
- N.D. Zelinsky Institute of Organic Chemistry (RU)
- Koltzov Institute of Developmental Biology (RU)
Publication Details
- Journal
- Mendeleev Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.71267/mencom.7633
- Citations
- 1
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Ministry of Education and Science of the Russian Federation