Analgesic Effect of Nabuprofen Combined with Ultrasound-guided Rectus Sheath Block on Patients Undergoing Gynecological Single-port Laparoscopic Surgery

Abstract Objective: The article aims to explore the analgesic effect of nabuprofen combined with ultrasound-guided rectus sheath block (RSB) on patients undergoing gynecological single-port laparoscopic surgery. Materials and Methods: This study involved 60 patients hospitalized between August 2021 and September 2022, who underwent elective single-port abdominal surgery for benign gynecological tumors. They were divided into two groups: Group A received intravenous nalbuphine (0.1 mg/kg) 30 min presurgery, while Group B did not. Both the groups underwent ultrasound-guided RSB. Indicators measured included pain hypersensitivity, Numerical Rating Scale (NRS) and Visual Analog Score pain scores at various postoperative intervals, remifentanil dosage, analgesic side effects, and heart rate (HR) and mean arterial pressure (MAP) at multiple surgical stages. Results: The pain threshold measured 24 h postsurgery indicates that Group A has a significantly lower threshold than both the preoperative baseline and Group B ( P < 0.05). In addition, the secondary hyperalgesia area around the incision is significantly larger in Group B compared to Group A ( P < 0.05). At T1, NRS pain scores significantly differ between the two groups ( P < 0.05), although both remain below 4, indicating mild-to-moderate pain. No significant difference in postoperative NRS scores is noted at 24 h ( P > 0.05). MAP and HR comparisons show no significant differences ( P > 0.05). Group A received lower intraoperative dosages of propofol and remifentanil ( P < 0.05) and had shorter recovery times than Group C ( P < 0.05). Group A also used the analgesic pump less frequently than Group B ( P < 0.05), which had a higher incidence of postoperative adverse reactions ( P < 0.05). Conclusion: Combining nalbuphine and ultrasound-guided rectus sheath nerve block can significantly improve patients’ overall pain. Moreover, it can significantly improve their prognosis, reduce the incidence of adverse reactions, and have important clinical application value.