Nanocomposite Hydrogels and Micro/Nanostructures for Printing Organoids
Organoids are 3D artificial miniature organs composed of a cluster of self-renewing and self-organizing cells <i>in vitro</i>, which mimic the functions of real organs. Nanotechnologies, including the preparation of nanomaterials and the fabrication of micro/nanostructures, have been proven to promote cell proliferation, guide cell differentiation, and regulate cell self-organization, showing great promise in engineering organoids. In this Perspective, different types of nanocomposite hydrogels for organoid culture are summarized, the effects of micro/nanostructures on organoid growth and development are discussed, and 3D bioprinting technologies for constructing organoid models are introduced.
Authors
- Bingda Chen
- Bin Shi (ORCID: https://orcid.org/0009-0008-4164-4888)
- Wenjing Guo
- Meng Su (ORCID: https://orcid.org/0000-0001-8485-2590)
- Wenqing Wang (ORCID: https://orcid.org/0000-0002-0990-0588)
- Long Wang (ORCID: https://orcid.org/0000-0001-5600-8157)
- Zhiyuan Sun (ORCID: https://orcid.org/0000-0002-4724-7508)
- Daixi Xie
- Yanlin Song (ORCID: https://orcid.org/0000-0002-0267-3917)
Institutions
- Macau University of Science and Technology (MO)
- Chinese Academy of Sciences (CN)
- Chinese PLA General Hospital (CN)
- Beijing National Laboratory for Molecular Sciences (CN)
- Institute of Chemistry (CN)
- University of Chinese Academy of Sciences (CN)
- Macao Polytechnic University (MO)
Publication Details
- Journal
- ACS Nano
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1021/acsnano.4c17587
- Citations
- 5
- Primary Topic
- 3D Printing in Biomedical Research
- Type
- article
- Field-Weighted Citation Impact
- 3.37
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Beijing National Laboratory for Molecular Sciences