The <scp>NLRP3</scp> inflammasome pathway contributes to chronic inflammation in experimental autoimmune uveitis
Overall, our findings support the idea that in the EAU model there is active inflammation, even 12 weeks post induction, and that it can be correlated to inflammasome activation. This contributes to the pathogenesis and chronicity of noninfectious uveitis, and our results emphasize that targeting the inflammasome pathway could be efficacious for noninfectious uveitis treatment.
Authors
- Odunayo O. Mugisho (ORCID: https://orcid.org/0000-0002-4519-6727)
- Ilva D. Rupenthal (ORCID: https://orcid.org/0000-0001-5997-5994)
- Avik Shome (ORCID: https://orcid.org/0000-0003-0739-2484)
- Rachael Louise Niederer (ORCID: https://orcid.org/0000-0002-4311-859X)
Institutions
- University of Auckland (NZ)
- New Zealand Christians in Science (NZ)
Publication Details
- Journal
- Animal Models and Experimental Medicine
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1002/ame2.70011
- Citations
- 5
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- Auckland Medical Research Foundation
- Maurice and Phyllis Paykel Trust
- Neurological Foundation of New Zealand
- Buchanan Charitable Foundation
- Health Research Council of New Zealand