Enhancing anti-CD3 mAb-mediated diabetes remission in autoimmune diabetes through regulation of dynamin-related protein 1(Drp1)-mediated mitochondrial dynamics in exhausted CD8+T-cell subpopulations
Our results point to a new immunotherapeutic approach that targets exhausted CD8<sup>+</sup> T cells' energy metabolism, offering valuable insights for advancing clinical strategies in T1D therapy.
Authors
- Xinyu Xu (ORCID: https://orcid.org/0000-0002-8584-9382)
- Zhangyao Su
- Yun Cai (ORCID: https://orcid.org/0000-0002-5402-8143)
- Lingling Bian
- Tao Yang (ORCID: https://orcid.org/0000-0002-5158-0987)
- Junjie Gu (ORCID: https://orcid.org/0000-0002-3393-9220)
- Jiang Yin
- Ruiling Zhao
- Yong Gu (ORCID: https://orcid.org/0000-0002-0482-1610)
- Hang Zhao
Institutions
- Nanjing Medical University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1186/s12916-025-04001-5
- Citations
- 4
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 7.27