Altered internetwork functional connectivity and graph analysis of occipital regions in patients with chronic rhinosinusitis accompanied by olfactory dysfunction

This study assessed whole-brain functional connectivity and network graph theory indices in patients with chronic rhinosinusitis with (CRSwOD) and without (CRSsOD) olfactory dysfunction. We also analyzed correlations between the abnormal network metrics and clinical indices. We acquired resting-state functional magnetic resonance images from 31 patients with CRSsOD, 26 with CRSwOD, and 25 healthy controls (HCs). Functional connectivity was computed and graph theory metrics were evaluated based on the Dosenbach-160 Atlas; relationships between neuroimaging indicators and clinical scales were assessed using Pearson correlation analysis. The results showed that CRSsOD patients had 11 edges with greater strength than HCs, CRSwOD patients had 1 greater edge than HCs, and CRSsOD patients had 5 greater edges than CRSwOD patients. Nodal degree centrality and efficiency in the right posterior occipital region were significantly altered in patients with CRSsOD compared with those in CRSwOD and in HCs. Five and two edges correlated with clinical scales in patients with CRSsOD and CRSwOD, respectively, whereas no correlations in global and nodal indicators were found. These results imply that distinct brain network patterns, particularly in the occipital cortex, could be a valid neuroimaging marker for related diagnosis and prognosis of CRSsOD and CRSwOD patients, and contribute to our better understanding of the central neural mechanisms of CRSwOD, providing new ideas for the clinical management of CRSwOD.