SCIENTIFIC AND METHODOLOGICAL APPROACH TO THE CHOICE OF POLYMERIC MATERIALS FOR TISSUE THERAPY

Introduction. The idea of using polymeric compositions in medicine that can modulate regeneration phases and directly influence them in order to improve the potential of recovery has found its application in the development of polymer-based compositions for the treatment of tissue damage. A wide range of polymers of natural and synthetic origin allows one to select the composition of the polymer composition or additionally chemically mod-ify it to impart new properties to the material. Currently created wound dressings often do not always allow achieving the expected therapeutic effects, so the task of creating new polymeric compositions is relevant and of great interest in medical society. The aim of this study is to develop a scientific and methodological approach to expanding the range of polymeric materials for the therapy of wound surfaces. Material and methods. The development of a scientific and methodological approach for an objective assessment of the prospects for creating polymeric materials for the therapy of wound surfaces was carried out using information retrieval databases (ScienceDirect, Wiley Online Library, Pub-Med). Results. Based on the results of the study of information retrieval and library databases, it was found that the main problem arising in the develop-ment of polymer compositions is adhesion - the total surface area of the drug contact with the wound increases the effectiveness of therapy due to the complex effect on the entire wound bed. The key parameter in this case is adhesion - the phenomenon of interaction between dissimilar bodies during their intermolecular contact. Polymer compositions can be used to significantly increase the efficiency of regeneration, as well as to create op-timal conditions in the wound microenvironment and protection from additional external influences. Biopharmaceutical features and main functional groups of polymeric materials were considered, which should be taken into account when choosing a composition for creating polymer compositions. Conclusion. The development of a scientific and methodological approach for an objective assessment of the prospects for creating polymeric mate-rials for the therapy of wound surfaces made it possible to formulate the main properties that should be taken into account when choosing the compo-sition of the polymer composition to create a finished product in the therapy of wound surfaces at various stages of healing.