HEXA-FC protein therapy increases skeletal muscle glucose uptake and improves glycaemic control in mice with insulin resistance and in a mouse model of type 2 diabetes
Given that skeletal muscle is a primary site of insulin resistance in individuals with type 2 diabetes, HEXA-FC protein therapy may open new avenues for therapeutic advancement in type 2 diabetes.
Authors
- Sihan Lin (ORCID: https://orcid.org/0000-0002-4422-9275)
- Matthew J. Watt (ORCID: https://orcid.org/0000-0003-4064-4188)
- Michael G. Leeming (ORCID: https://orcid.org/0000-0001-8981-0701)
- Liwei Dong (ORCID: https://orcid.org/0000-0003-2116-1674)
- Chieh-Hsin Yang (ORCID: https://orcid.org/0000-0003-4360-670X)
- Nicholas A. Williamson (ORCID: https://orcid.org/0000-0002-2173-3452)
- Kim Loh (ORCID: https://orcid.org/0000-0003-3781-1926)
- Krishneel Prasad (ORCID: https://orcid.org/0000-0003-1085-9591)
- Magdalene K. Montgomery (ORCID: https://orcid.org/0000-0003-2551-4174)
- Jacqueline Bayliss (ORCID: https://orcid.org/0000-0002-7324-3551)
- Zixi Cheng (ORCID: https://orcid.org/0000-0002-3722-6455)
Institutions
- The University of Melbourne (AU)
- Walter and Eliza Hall Institute of Medical Research (AU)
- St Vincents Institute of Medical Research (AU)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-03-29
- DOI
- https://doi.org/10.1007/s00125-025-06413-7
- Citations
- 2
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- University of Melbourne
- National Health and Medical Research Council