Randomized Phase III Study of EGFR Tyrosine Kinase Inhibitor and Intercalated Platinum-Doublet Chemotherapy for Non–Small Cell Lung Cancer Harboring <i>EGFR</i> Mutation
The intercalation of cisplatin plus pemetrexed after the response to EGFR TKI improved PFS but not OS compared with EGFR TKI monotherapy as the first-line treatment for patients with advanced NSqNSCLC harboring EGFR mutation.
Authors
- Ryo Toyozawa (ORCID: https://orcid.org/0009-0002-7688-5725)
- Shintaro Kanda (ORCID: https://orcid.org/0000-0001-7864-3928)
- Toshihide Yokoyama (ORCID: https://orcid.org/0000-0002-5595-5010)
- Haruyasu Murakami (ORCID: https://orcid.org/0000-0003-2416-546X)
- Nobuyuki Yamamoto (ORCID: https://orcid.org/0000-0002-7342-0853)
- Hirokazu Taniguchi (ORCID: https://orcid.org/0000-0003-2414-8344)
- Seiji Niho (ORCID: https://orcid.org/0000-0001-9480-5923)
- Eiji Iwama (ORCID: https://orcid.org/0000-0001-8252-290X)
- Koichi Azuma (ORCID: https://orcid.org/0000-0001-5040-5856)
- Yosuke Kawashima (ORCID: https://orcid.org/0000-0002-9824-6572)
- Yukio Hosomi (ORCID: https://orcid.org/0000-0002-3849-5905)
- Satoshi Hara (ORCID: https://orcid.org/0000-0003-1936-7163)
- Yutaka Fujiwara (ORCID: https://orcid.org/0000-0001-6981-0800)
- Takayasu Kurata (ORCID: https://orcid.org/0000-0003-4123-3567)
- Shogo Nomura (ORCID: https://orcid.org/0000-0001-8734-6984)
- Akihiro Bessho (ORCID: https://orcid.org/0000-0002-0394-7377)
- Yoshitaka Zenke (ORCID: https://orcid.org/0000-0002-7641-9065)
- Yuichiro Ohe (ORCID: https://orcid.org/0000-0002-6137-073X)
- Hiroshi Tanaka (ORCID: https://orcid.org/0000-0002-8003-7326)
- Yasutaka Watanabe (ORCID: https://orcid.org/0000-0002-3679-4864)
Institutions
- Kurume University (JP)
- Kansai Medical University (JP)
- University of Nagasaki (JP)
- Kyushu University (JP)
- Wakayama Medical University (JP)
- Tokyo Metropolitan Komagome Hospital (JP)
- National Cancer Centre Japan (JP)
- Shizuoka Cancer Center (JP)
- National Cancer Center (US)
- Kurashiki Central Hospital (JP)
- Niigata Cancer Center Hospital (JP)
- National Hospital Organization Kyushu Cancer Center (JP)
- Okayama Red Cross General Hospital (JP)
- Saitama Cancer Center (JP)
- Itami City Hospital (JP)
- Shinshu University Hospital (JP)
- Aichi Cancer Center (JP)
- National Cancer Center Hospital East (JP)
- Tokyo National Hospital (JP)
- Sendai Kousei Hospital (JP)
- Nagasaki University (JP)
- The University of Tokyo (JP)
- Dokkyo Medical University (JP)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-3532
- Citations
- 6
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 9.11