Novel regulation mechanism of histone methyltransferase SMYD5 in rheumatoid arthritis
Together, these findings suggest that SMYD5 is a dual target for regulating synovial fibroblast homeostasis and the pathogenesis of RA. Targeting SMYD5 through local treatment strategies may provide a novel therapeutic approach for RA, particularly when combined with immunotherapy.
Authors
- Zhenghua Su
- Yongfeng Hu (ORCID: https://orcid.org/0000-0002-7510-9444)
- Jialin Zhao (ORCID: https://orcid.org/0000-0002-1165-8911)
- Subei Tan (ORCID: https://orcid.org/0000-0001-9869-6074)
- Chenxi Xiao (ORCID: https://orcid.org/0000-0001-5885-1930)
- Mengting He (ORCID: https://orcid.org/0000-0001-8773-3167)
- Chunxiang Fan
- Jie Xu (ORCID: https://orcid.org/0000-0002-3270-1659)
- Xinhua Liu (ORCID: https://orcid.org/0000-0002-9972-8215)
- Yuhui Li (ORCID: https://orcid.org/0000-0002-6131-8595)
- Zhongzheng Li (ORCID: https://orcid.org/0000-0002-3380-2793)
- Jiayao Liu (ORCID: https://orcid.org/0000-0003-2160-0438)
Institutions
- Fudan University (CN)
- Pudong Medical Center (CN)
- Ningbo No.6 Hospital (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1186/s11658-025-00707-9
- Citations
- 3
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 5.31