Diagnostic accuracy of smear microscopy, mycobacterial culture, and GeneXpert MTB/RIF assay for diagnosis of subclinical tuberculosis: a retrospective multicenter study
Subclinical tuberculosis (TB) poses a major challenge to public health interventions, especially in the wake of the COVID-19 pandemic. However, a substantial proportion of individuals have absence or non-recognized symptoms, which put great pressure on clinical diagnosis. In this study, we conducted a retrospective multicenter study to assess the performance of smear microscopy, mycobacterial culture, and GeneXpert MTB/RIF (Xpert) in diagnosis of subclinical TB. We also aimed to determine the proportion and risk factors of subclinical TB in China in order to accelerate progress towards global milestones and targets for the End TB Strategy.
Authors
- Yu Pang (ORCID: https://orcid.org/0000-0001-6803-9807)
- Yanhong Yu (ORCID: https://orcid.org/0000-0002-1652-201X)
- Yuanyuan Shang (ORCID: https://orcid.org/0000-0002-3538-7730)
- Cong Yao
- Jin Shi (ORCID: https://orcid.org/0009-0007-9379-5998)
- Shanshan Li (ORCID: https://orcid.org/0000-0001-8293-9676)
- Bo Li (ORCID: https://orcid.org/0009-0001-4607-5329)
- Weicong Ren
- M Y Gao (ORCID: https://orcid.org/0000-0002-4084-780X)
Institutions
- Capital Medical University (CN)
- Center for Tuberculosis Control of Guangdong Province (CN)
- Beijing Chest Hospital (CN)
- Heilongjiang Center for Tuberculosis Control and Prevention (CN)
- Shenyang 242 Hospital (CN)
- Beijing Center for Disease Prevention and Control (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1128/spectrum.01888-24
- Citations
- 1
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Beijing Nova Program