Prediction of Potential Drugs Targeting Acute Pancreatitis Based on the HLA-DR-Related Gene-Monocyte Infiltration Regulatory Network
We identified 3 HLA-DR-related genes (HLA-DRA, HLA-DRB1, and HLA-DRB5) and 3 coregulatory nodes (UCP2, GK, and SAMHD1), which were associated with AP severity and monocyte abundance. Based on these genes, we predicted 20 potential therapeutic agents for AP.
Authors
- Yiming Lu (ORCID: https://orcid.org/0000-0001-8005-2705)
- Shengyi Shi (ORCID: https://orcid.org/0000-0001-5028-5372)
- Jing Ye (ORCID: https://orcid.org/0000-0003-3507-5355)
- Lan Hu
- Jie Gao (ORCID: https://orcid.org/0000-0001-9180-2276)
- Wei Xu (ORCID: https://orcid.org/0009-0008-1596-5960)
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- Jiading District Central Hospital (CN)
Publication Details
- Journal
- Biomedical Engineering and Computational Biology
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1177/11795972251328458
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00