<i>In vitro</i> interactions of berbamine hydrochloride and azoles against <i>Aspergillus fumigatus</i>
The combination of berbamine hydrochloride and posaconazole effectively enhances azole sensitivity in <i>Aspergillus fumigatus</i> by reducing efflux pump activity and increasing reactive oxygen species levels. The findings offer a promising strategy to combat azole resistance in invasive fungal infections.
Authors
- Yinping Chen
- Han‐Mo Yang (ORCID: https://orcid.org/0000-0003-4848-0878)
- Yi Sun (ORCID: https://orcid.org/0000-0002-4489-3803)
- Heng Zhang (ORCID: https://orcid.org/0009-0002-6618-5311)
- Fan Dong (ORCID: https://orcid.org/0000-0001-6730-0612)
- Yizheng Zhou
- Xinyi Tao
Institutions
- Yangtze University (CN)
- Pudong New Area People's Hospital (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1128/spectrum.03184-24
- Citations
- 3
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 4.19
Funders
- Hebei Provincial Key Research Projects