Identification of a mimotope of a complex gp41 human immunodeficiency virus epitope related to a non-structural protein of <i>Hepacivirus</i> previously implicated in Kawasaki disease

The development of protective HIV vaccines continues to remain a significant challenge. Many of the broadly neutralizing antibodies require a significant number of mutations, suggesting that traditional vaccines will not be able to recapitulate these types of responses. We have discovered an antibody that has Ab dependent cell cytotoxicity (ADCC) activity against HIV even when mutating the heavy chain of that antibody to germline. As a potential target for vaccines, this offers a distinct advantage: a few immunizations should directly stimulate B cells harboring those specific germline variable chains for expansion. This study sought to identify potential peptide targets that could be formulated into such a vaccine. We identified a peptide that both germline and mature antibodies can recognize. Initial autoantigen screens and consideration of inflammatory disorders suggest this identified antigen is a feasible approach to move forward into pre-clinical models.