A plant virus attenuates the Toll immune pathway by degradation of Pellino to facilitate viral infection in insect vectors
Plant virus diseases pose a serious threat to global crop production. Nearly half of the known plant viruses are persistently transmitted by insect vectors, and these plant viruses must counteract various innate immune responses to maintain persistent infection. Here, we uncover a novel counter-defense mechanism against Toll antiviral defense. Our research showed that LsPellino exerts antiviral function by interacting with LsTube and participating in the Toll immune pathway. To counteract this immunity, a plant virus, rice stripe virus, attenuates the Toll immune pathway and promotes viral infection by using viral nonstructural protein NS3 to mediate the degradation of LsPellino in its insect vector, <i>Laodelphax striatellus</i>. This study not only contributes to a better understanding of the arms race between viruses and insect vectors but also provides a new perspective for controlling the transmission of plant viruses.
Authors
- Yihui Du (ORCID: https://orcid.org/0000-0003-0959-8339)
- Gang Lü (ORCID: https://orcid.org/0000-0001-8017-2192)
- Bo-Xue Li
- Chuan‐Xi Zhang (ORCID: https://orcid.org/0000-0002-7784-1188)
- Yujuan He (ORCID: https://orcid.org/0000-0002-3349-8082)
- Jun‐Min Li (ORCID: https://orcid.org/0000-0002-8385-8912)
- Lin Lin (ORCID: https://orcid.org/0000-0002-7464-1172)
- Jianping Chen (ORCID: https://orcid.org/0000-0002-3849-4080)
- Xiao‐Wei Wang (ORCID: https://orcid.org/0000-0002-7472-3944)
- Yan Zhang (ORCID: https://orcid.org/0000-0001-8738-2053)
- Yanhua Lü (ORCID: https://orcid.org/0000-0003-1338-4149)
- Yu-Hua Qi
Institutions
- Ningbo University (CN)
- Ministry of Agriculture (EE)
- Institute of Plant Protection (CN)
- Rural Resources (US)
- State Key Laboratory of Rice Biology
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Virology
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1128/jvi.00021-25
- Citations
- 1
- Primary Topic
- Plant Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Ningbo
- National Key Research and Development Program of China
- Natural Science Foundation of Zhejiang Province