Evaluation of Antihypertensive Activity of Aqueous-methanol Extract of Sida ovata Grown in Kaura Namoda, Zamfara State

The present study aimed at evaluating antihypertensive activity of aqueous-methanol extract of Sida ovata on normal saline induced-hypertensive rats. The induced-hypertensive rats were administered 100, 200, 400 and 800 mg/kg doses of extract of S. ovata and their Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Arterial Blood Pressure (MABP) and Pulse Pressure (PP)) were monitored for four weeks. The SBP which were 121.25, 127.55, 138.25 and 141.50 mmHg for week 1, 2, 3 and 4 respectively were lowered to almost normal by 100 mg/kg for week 1 and 800 mg/kg for weeks 2, 3 and 4 respectively. DBP were lowered to almost normal level by 400 mg/kg of the extract except for week 4 that utilized 800 mg/kg to achieve similar result. PP required 400 mg/kg to lower it to almost normal except week 1 that achieved similar result with 200 mg/kg. While 100 and 400 mg/kg were required to lower the MABP to almost normal level for week 1 and 2 respectively, 800 mg/kg was required for weeks 3 and 4. The results showed a dose-dependent decrease in blood pressure. Int