Transforming Growth Factor β1 Protects Against Ischemic Demyelination via Regulating Microglial Lipid Metabolism Pathway
TGF-β1 relieved cognitive deficit, demyelinating lesions, and microglia-mediated neuroinflammation in bilateral common carotid artery stenosis modeling by reducing abnormal lipid droplet accumulation and dysfunction of the autophagy-lysosomal pathway in microglia. Clinically, staged activation of the TGF-β1 pathway may become a potential target and promising treatment for ischemic white matter lesions and vascular cognitive impairment.
Authors
- Zhigang He (ORCID: https://orcid.org/0000-0002-8999-9345)
- Yi Xie (ORCID: https://orcid.org/0000-0001-5082-9173)
- Shuai Liu (ORCID: https://orcid.org/0009-0005-7815-0724)
- Wei Wang (ORCID: https://orcid.org/0000-0002-9176-5150)
- Xinyue Wang (ORCID: https://orcid.org/0000-0001-9422-2955)
- Hang Zhang (ORCID: https://orcid.org/0000-0001-7639-0031)
- Minjie Xie (ORCID: https://orcid.org/0000-0001-7317-3066)
- Zhiyuan Yu (ORCID: https://orcid.org/0000-0001-6157-3986)
Institutions
- World Wide Web Consortium (US)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Stroke
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1161/strokeaha.124.048206
- Citations
- 6
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.05