Polygenic overlap of substance use behaviors and disorders with externalizing and internalizing problems independent of genetic correlations
These results highlight the importance of the externalizing pathway in SUDs as well as the limited role of the internalizing pathway in SUBs. As MiXeR is not intended for the identification of specific genes, further studies are needed to reveal the underlying shared mechanisms of these traits.
Authors
- Markos Tesfaye (ORCID: https://orcid.org/0000-0002-3351-701X)
- Piotr Jahołkowski (ORCID: https://orcid.org/0000-0001-9408-3107)
- Ole A. Andreassen (ORCID: https://orcid.org/0000-0002-4461-3568)
- Vera Fominykh
- Alexey A. Shadrin (ORCID: https://orcid.org/0000-0002-7467-250X)
- Guy Hindley (ORCID: https://orcid.org/0000-0003-1666-4701)
- Laila Al‐Soufi (ORCID: https://orcid.org/0000-0003-2975-1636)
- Linn Rødevand (ORCID: https://orcid.org/0000-0001-5967-6601)
- Javier Costas (ORCID: https://orcid.org/0000-0003-0306-3990)
- Romain Icick (ORCID: https://orcid.org/0000-0002-5078-4048)
Institutions
- Inserm (FR)
- University of Oslo (NO)
- Universidade de Santiago de Compostela (ES)
- Université Paris Cité (FR)
- Complejo Hospitalario Universitario de Santiago (ES)
- Laboratoire d'Optique Appliquée (FR)
- Complexo Hospitalario Universitario A Coruña (ES)
- Instituto de Investigación Sanitaria de Santiago (ES)
- Servicio Gallego de Salud (ES)
- University of Bergen (NO)
Publication Details
- Journal
- Psychological Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/s0033291725000108
- Citations
- 2
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.63
Funders
- Stiftelsen Kristian Gerhard Jebsen
- European Commission
- Universitetet i Oslo
- Norges Forskningsråd
- Instituto de Salud Carlos III
- Helse Sør-Øst RHF
- H2020 European Research Council