Successful clearance of persistent <i>Staphylococcus aureus</i> pneumonia with high-dose continuous infusion cefazolin
Here, we describe a patient with incomplete clearance of MSSA pneumonia despite two 5- to 7-day courses of cefazolin 8 g daily CI. Following a 14-day course of cefazolin 10 g daily CI, the patient's fever and leukocytosis rapidly resolved without direct evidence of drug-related toxicity. This case report provides evidence for the safe and effective use of high-dose cefazolin CI in the clearance of persistent MSSA pneumonia.
Authors
- Dan F. Smelter (ORCID: https://orcid.org/0000-0001-9181-0786)
- Christopher R. Frei (ORCID: https://orcid.org/0000-0002-0692-4787)
- Annie A Smelter (ORCID: https://orcid.org/0009-0003-9586-6228)
Institutions
- Austin College (US)
- The University of Texas at San Antonio Health Science Center (US)
- The University of Texas at San Antonio (US)
- The University of Texas at Austin (US)
Publication Details
- Journal
- ASM Case Reports
- Published
- 2025-03-31
- DOI
- https://doi.org/10.1128/asmcr.00114-24
- Citations
- 1
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Institute on Aging
- National Institute of General Medical Sciences
- National Center for Advancing Translational Sciences