Circulating Tumor DNA Methylation Is a Biomarker of Poor Recurrence-free Survival in Locally-Advanced Rectal Cancer
The present study demonstrates that elevated ctDNA methylation of the <i>SOX11</i> gene is a biomarker for reduced RFS after curative-intent resection of LARC. Patients with high ctDNA methylation of the <i>SOX11</i> gene may not be optimal candidates for LARC resection. A prospective study is necessary to further validate <i>SOX11</i> ctDNA methylation as a biomarker for RFS of patients with LARC.
Authors
- Makoto Takahashi (ORCID: https://orcid.org/0000-0002-2452-0268)
- Shoko Kochi
- Hirotaka Momose
- Robert M. Hoffman (ORCID: https://orcid.org/0000-0002-0049-0041)
- Shun Ishiyama
- Kazuhiro Sakamoto (ORCID: https://orcid.org/0000-0002-5166-9068)
- Kiichi Sugimoto (ORCID: https://orcid.org/0000-0003-1210-2920)
- Ryoichi Tsukamoto (ORCID: https://orcid.org/0000-0002-3809-6875)
- Kumpei Honjo (ORCID: https://orcid.org/0000-0002-2250-6008)
- Takahiro Irie
- Yuki Tsuchiya
- Miyuki Toake
Institutions
- Juntendo University (JP)
- University of California San Diego (US)
- AntiCancer (United States) (US)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-03-28
- DOI
- https://doi.org/10.21873/anticanres.17537
- Citations
- 1
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.05